Subjects: Medicine, Pharmacy >> Clinical Medicine Subjects: Biology >> Bioengineering Subjects: Physics >> Electromagnetism, Optics, Acoustics, Heat Transfer, Classical Mechanics, and Fluid Dynamics submitted time 2019-01-02
Abstract： Objective To investigate the effects of transcranial magnetoelectric stimulation (TMES) on temporal lobe epilepsy rats induced by kainic acid (KA). Methods 62 rats were divided into pretreatment (32 in total) and treatment (30 in total) groups according to the random number table method. The pretreatment group was further divided into 4 groups, and each group was stimulated by 0 %, 25%, 50%, 75% of the maximum current intensity (MCI) of the therapeutic apparatus respectively. According to the therapeutic efficacy, the optimal stimulation parameters under the experimental conditions was determined. The treatment group was further divided into 3 groups according to the random number table method, 10 in each group. Two groups (epilepsy-stimulating group, epilepsy-non-stimulating group) were epilepsy model rats that met the inclusion criteria. The stimulation parameters in the stimulating group were the best stimulation parameters explored in the pretreatment group; the rats in the non-stimulating group were treated the same before and after stimulation as the stimulating group. However, the therapeutic device has no effective energy output. The rats of third group difined as control were unmodeled control rats. All rats in the three groups were stimulated once a day for 40 minutes each for 14 days. The behavioral, histological and electrophysiological changes in the three groups of rats were recorded and compared to evaluate the efficacy of TMES therapy in epileptic rats. Results 50% MCI is the best stimulus intensity. The frequency of epileptic waves in epilepsy-stimulated rats was significantly lower than that in non-stimulated epileptic rats [(30.210 ± 4.580) beats/min vs. (31.380 ± 4.247) beats/min]. The difference was statistically significant (t = 3.235, P=0.001). The results of Timm staining showed that there was a statistically significant difference in the degree of staining between the three groups (F=17.429, P=0.000). The level of Timm staining in the inner molecular layer of dentate gyrus of the hippocampus in the epilepsy-stimulated group was significantly lower than that in the non-stimulated group, and the difference was statistically significant (P=0.027). Conclusion Transcranial magnetoelectric treatment can influence the formation of dentate gyrus neurons loop by improving epileptic rat dentate gyrus in epileptogenesis in changes of molecular layer organization degree, thereby reducing the frequency of epileptic EEG seizures.
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Awaiting Review
Subjects: Biology >> Bioengineering Subjects: Biology >> Biomedical Laboratory Science Subjects: Physics >> Electromagnetism, Optics, Acoustics, Heat Transfer, Classical Mechanics, and Fluid Dynamics submitted time 2017-03-17
Abstract：[目的] 临床观察脑功能康复仪（脑康仪）对脑循环和脑功能的影响。[方法] 将脑血管病患者180例，分为脑梗塞组、脑动脉硬化症组、椎-基底动脉供血不足组，每组各60例，按来诊的先后次序分为药物治疗组和仪器治疗组，各30例。药物治疗组按各病种的治疗常规投药，仪器治疗组应用奥博脑复康治疗仪，连续治疗 30 天。选用反映脑血流动力学变化的经颅多普勒超声（TCD）和反映脑功能变化的脑电地形图（BEAM）作为观测指标。[结果] 在脑梗塞患者中实验组的疗效明显优于对照组（P﹤0.01），而且 TCD 和 BEAM 在两组间均呈现显著的差异性（P﹤0.05 或﹤0.01）；在脑动脉硬化症患者中实验组的疗效优于对照组（P﹤0.05），而且 TCD 和 BEAM 在两组间均呈现显著的差异性（P﹤0.01）或﹤0.05）；在椎-基底动脉供血不足患者中，实验组的疗效明显优于对照组（P﹤0.05），而且TCD、BEAM 在两组间亦呈现报为显著的差异性（P﹤0.01）。[结论] 应用脑康仪可明显改善脑血流动力学状态，增加脑血流量，强化脑的功能活动，消除脑部病灶周围的组织水肿和肿胀，缓解脑血管痉挛，改善脑组织的血液供给和缺氧状态提高脑组织的新陈代谢，促进病灶同侧或对侧的侧支循环形成，激活处于抑制状态的脑细胞，增强大脑的综合分析能力和记忆功能。可用于治疗脑梗塞、脑动脉硬化症、椎-基底动脉供血不足以及由于强化记忆所致脑功能减退。
Peer Review Status:Awaiting Review
Subjects: Biology >> Bioengineering Subjects: Physics >> Electromagnetism, Optics, Acoustics, Heat Transfer, Classical Mechanics, and Fluid Dynamics submitted time 2017-02-13
Abstract：[目的] 评价经颅磁电抑郁症（失眠）治疗仪（商品名：奥博百忧度）治疗抑郁症的有效性及安全性。[方法] 对 80例轻、中度抑郁症患者进行了随机、安慰对照、多中心4周临床试验,其中治疗组和对照组各 40例。治疗组使用经颅磁电抑郁症（失眠）治疗仪进行治疗，对照组使用经颅磁电抑郁症（失眠）治疗仪模拟治疗（音频安慰）。[结果] 临床试验研究结果表明，治疗 4 周后对照组的总显效率和总有效率分别为5.00%（2/40）和 35.00%（14/40），其 95%的可信区间分别为（0.00～11.75）和（20.22～49.78），治疗组的总显效率和总有效率分别为 65.00%（26/40）和 80.00%（32/40），其 95%的可信区间分别为（50.22～79.78）和（67.60～92.40），各中心效应有差别（P=0.0009）；两组总有效率和总显效率的优效性检验 P<0.0001，且治疗组高于对照组，说明治疗组优于对照组。两组均无不良反应。[结论] 经颅磁电抑郁症（失眠）治疗仪（商品名：奥博百忧度）治疗抑郁症使用安全，疗效确切，尤其在“抑郁、有罪感、睡眠障碍、工作和兴趣、迟缓、激惹、焦虑”等主要症状方面得到明显改善。
Peer Review Status:Awaiting Review
Subjects: Biology >> Bioengineering Subjects: Physics >> Electromagnetism, Optics, Acoustics, Heat Transfer, Classical Mechanics, and Fluid Dynamics submitted time 2017-02-03
Abstract：[目的] 评价经颅磁电脑病治疗仪（商品名：奥博阿尔茨海默治疗仪）治疗轻、中度阿尔茨海默病(Alzheimer disease，AD)的有效性及安全性。[方法] 对 80 例轻、中度 AD[Hachinski 缺血量表评分≤4 分，痴呆程度（CDR=1.0）或（CDR=2.0）]患者进行了随机、安慰对照、多中心8周临床试验,其中治疗组和对照组各40例。所有入选病例均给予正规的内科基础治疗和规范化护理，治疗组使用经颅磁电脑病治疗仪进行治疗，对照组使用安慰经颅磁电脑病治疗仪进行模拟治疗。[结果] 临床试验研究结果表明，治疗8周时,治疗组较对照组简易精神状态评价（MMSE）、阿尔茨海默认知评价（ADAS-Cog）和日常生活能力评价（ADL）分数显著改善（组间差异P依次<0.001、0.0001、0.05）。治疗 4周时，MMSE和 ADAS分数已有提高(组间差异 P依次<0.05、0.01)。两组均无不良反应。[结论] 根据试验统计结果，经颅磁电脑病治疗仪治疗轻、中度阿尔茨海默病具有治疗效果，对患者的精神状态、认知行为和日常生活自理能力有较好的改善作用，且该治疗仪使用安全。
Peer Review Status:Awaiting Review
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