Subjects: Biology >> Botany >> Applied botany submitted time 2020-03-24 Cooperative journals: 《广西植物》
Abstract：通过对采自广西24 个县（市）的1 147 份青藓科植物标本的逐一鉴定及相关文献的查阅，确认广西青藓科植物有11 属、44 种，其中包括广西青藓科植物新纪录属1 属，即拟异叶藓属（Pseudokindbergia），新纪录种7 种，分别为拟异叶藓（P. dumosa）、匐枝青藓（Brachythecium procumbens）、阔叶尖喙藓（Oxyrrhynchium latifolium）、泛生尖喙藓（O. vagans）、华东细喙藓（Rhynchostegiella sinensis）、长肋拟青藓（Sciuro-hypnum populeum）和弯叶拟青藓（S. reflexum）。该文提供了修订后的广西青藓科植物名录，并对其中的新纪录属、种的主要形态学识别特征、生境和地理分布等进行了详细描述。
Subjects: Biology >> Zoology submitted time 2017-10-10 Cooperative journals: 《动物营养学报》
Abstract：本试验旨在研究饲粮中添加不同水平的肌醇对獭兔皮肤中β-连环蛋白（β-catenin）和激素敏感酯酶（HSL）表达的影响。选取（40±1）日龄的同期断奶獭兔120只(公母各占1/2)，随机分成4组，每组30只。在4组獭兔的饲粮中分别添加0、25、50、75 mg/kg的肌醇，试验期为3个月。在试验的第30天（2月龄）、第60天（3月龄）和第90天（4月龄），分别取腹部、背中部、臀部皮肤，采用免疫组织化学和蛋白质印迹（Western blot）法对β-catenin和HSL的表达和定位进行检测。结果表明：β-catenin在毛囊中广泛表达，在毛根鞘细胞和毛乳头均有棕黄色阳性反应细胞。HSL在毛根鞘细胞，尤其是在内根鞘细胞内，呈现非常明显的棕黑色强阳性表达。饲粮中添加50 mg/kg肌醇可以极显著增加2~4月龄獭兔背中部皮肤毛囊中β-catenin和HSL阳性表达细胞的平均灰度值（P＜0.01），极显著增加4月龄獭兔背中部、腹部和臀部皮肤毛囊中β-catenin和HSL阳性表达细胞的平均灰度值（P＜0.01）。结果提示，肌醇能够通过上调4月龄獭兔毛囊中β-catenin和HSL的表达来促进毛囊的发育，在本试验中，饲粮肌醇水平达到50 mg/kg时效果最佳。
Subjects: Biology >> Bioengineering submitted time 2017-07-24 Cooperative journals: 《中国生物工程杂志》
Abstract： Rare diseases, also known as "orphan diseases", refer to the diseases which have a very low morbidity. Most of orphan diseases are congenital disease or chronic disease, and they are often dangerous. With the improvement of public awareness, support of national policy and development of diagnosis and treatment technology, orphan drugs market has gradually developed. Sales of the orphan drugs increased year by year and several "heavy bombs" have arisen. The international pharmaceutical companies began to seize the orphan drugs market and intensified drug development. The number of orphan drugs under research and development is more than 500, which are mainly for rare cancer, hereditary diseases, neurological diseases, infectious diseases and autoimmune diseases. Developed countries and regions have mature management system and market of orphan drugs, but China is still relatively backward in this regard. This paper analyzes the dilemmas of domestic orphan drugs market and puts forward some suggestions for these dilemmas, hoping to promote the development of the domestic orphan drugs market.
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