江西地产苍耳草抑制坏死性凋亡(necroptosis)活性部位化学成分研究(Ⅰ)

Subjects: Biology >> Botany >> Applied botany submitted time 2021-12-19 Cooperative journals: 《广西植物》

盛天露 付璐鹭 许俊申 尚锐峰 陈钟文 刘峰 刘华

Abstract： Herba Xanthii is a traditional folk medicinal plant.The 50% ethanol eluting faction of Xanthium mongolicum in Jiangxi had significant activity to inhibit necroptosis. In order to investigate the chemical constituents, the active fractions of X. sibiricum were isolated and purified by various chromatographic methods such as repeated silica gel column chromatography, Sephadex LH-20 column chromatography, preparative high performance liquid chromatography and recrystallization to yield 14 compounds. Their structures were established on the basis of NMR, MS spectraoscopic analyses and comparison with lirerature date. Fourteen compounds were isolated from the active part and identified as hydroxydihydrobovolide(1), raspberry ketone(2), salicyl alcohol(3), 4-hydroxyl-acetophenone(4), 4-hydroxybenzaldehyde(5), ethyl caffeate(6), ferulaldehyde(7), isoscopletin(8), 3,3'-bis(3,4-dihydro-4-hydroxy-6 -methoxy-2H-1-benzopyran)(9)，axillarin (10)，quercetin (11)，(+) pinoresinol(12)， β-sitosterol(13) and palmatic acid(14). Compounds 1, 2, 3, 4, 7, 8, 9, 10 were isolated from Xanthium mongolicum for the first time．

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