Subjects: Biology >> Botany >> Applied botany submitted time 2021-04-29 Cooperative journals: 《广西植物》
Abstract： To study the chemical constituents of China endemic plant Rubia oncotricha, the compounds were isolated and purified by silica gel, ODS, Sephadex LH-20, and their structures were elucidated by modern spectroscopic techniques. Fifteen anthraquinone compounds were isolated and identified from Rubia oncotricha, they are 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-(6'-O-acetyl)-α-rhamnosyl(1→2)-β-glucoside (1), 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-α-rhamnosyl(1→2)-β-glucoside (2), 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-(3'-O-acetyl)-α-rhamnosyl (1→2)-β-glucoside (3), 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-β-glucoside (4), 1,3,6-trihydroxy-2-hydroxymethyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-β-D-glucopyranoside (5), 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-(6'-O-acetyl)-β-D-glucopyranoside (6), physcion-8-O-β-D-glucopyranoside (7), emodin-8-O-β-D-glucopyranoside (8), digiferruginol-11-O-β-gentiobioside (9), 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-(6'-O-acetyl)-β-D-xylopyranosyl-(1→2)-β-Dglucopyranoside (10), 6-hydroxyrubiadin (11), 1,2-dihydroxyanthraquinone (12), chrysophanol (13), 6-hydroxyxanthopurpurin (14), 1,3-dihydroxyanthraquinone (15). Compounds 7, 8, 14 are isolated from the genus of Rubia for the first time, compound 1~6, 9, 10, 12, 13 are isolated from Rubia oncotricha for the first time.
Subjects: Biology >> Bioengineering submitted time 2018-10-09 Cooperative journals: 《中国生物工程杂志》
Abstract：乙型肝炎病毒(hepatitis B virus，HBV)是引起病毒性乙型肝炎的主要病原体，依然是影响人类健康的全球性问题。干扰素和核苷（酸）类似物是国内外获批上市的主要抗乙肝病毒药物。替诺福韦和恩替卡韦在国外抗乙肝病毒药物市场上占据巨大的份额，而早期推出的拉米夫定和阿德福韦酯因其耐受性和安全性等原因所占市场份额逐年减少。国外有39种抗乙肝病毒新药正处于临床阶段。国内临床上使用更多的是口服核苷(酸)类似药物，尤其是恩替卡韦近年来占近一半抗乙肝药物市场。抗乙肝病毒药物城市零售前10的企业市场份额占整个零售的91.8%，市场集中度较高。虽然国内乙肝新药研发水平与欧美还存在较大差距，但是在国内创新政策推动下，出现了东阳光、正大天晴等20余家从事研发企业，并取得一定的成效。基于我国抗乙肝病毒药物发展困境，提出了继续完善抗乙肝病毒药物医保政策、部署和实施乙型肝炎重大专项等研发项目、推进产学研用深度融合等对策建议。
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