Microcirculation Dysfunction in Age-related Cognitive Impairment

作者： Chen Xi-Xi ¹ Su Tao ¹ Chen Xi-Xi ²
作者单位：

1. Chinese Acad Sci, State Key Lab Brain & Cognit Sci, Inst Biophys, Beijing 100101, Peoples R China.

2. Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China.
提交时间：2016-05-11 08:40:38

摘要: Microcirculation dysfunction is regarded as one of important pathologies of senility, degeneration, immune disorder and many other diseases. Cerebral circulation insufficiency, energetic dysmetabolism, hypoxia-ischemia and metabolites accumulation in Alzheimer's disease (AD) have a close relation with microcirculation dysfunction. Here, we review microcirculation dysfunction playing an important role in hyperphosphorylation of Tau, A beta aggregation and cognitive impairment induced by accumulation of formaldehyde and D-ribose.

GLYCATION END-PRODUCTS SENSITIVE AMINE OXIDASE ALZHEIMERS-DISEASE MICROVASCULAR PATHOLOGY OXIDATIVE STRESS D-RIBOSE IN-VIVO TAU HYPERPHOSPHORYLATION ENDOTHELIAL DYSFUNCTION ENDOGENOUS FORMALDEHYDE

期刊： PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
分类： 生物学 >> 生物物理学 >> 生物物理、生物化学与分子生物学
引用： ChinaXiv:201605.01359 (或此版本 ChinaXiv:201605.01359V1)
DOI:10.12074/201605.01359V1
CSTR:32003.36.ChinaXiv.201605.01359.V1
推荐引用方式： Chen Xi-Xi,Su Tao,Chen Xi-Xi.(2016).Microcirculation Dysfunction in Age-related Cognitive Impairment.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS.[ChinaXiv:201605.01359] (点此复制)

版本历史

[V1]

2016-05-11 08:40:38

ChinaXiv:201605.01359V1

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