Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation

作者： Wang, Huiru ¹ Wu, Yanhong ¹ Zhou, Chunxia ¹ Ma, Wenbo ¹ Zhang, Youhui ¹ Zhang, Shuren ¹ Wang, Huiru ² Wu, Yanhong ² Zhou, Chunxia ² Ma, Wenbo ² Zhang, Youhui ² Zhang, Shuren ² Wang, Huiru ³ Wu, Yanhong ³ Wang, Lin ³ Zhou, Chunxia ³ Ma, Wenbo ³ Zhang, Youhui ³ Zhang, Shuren ³ Sun, Qing ⁴ Wang, Lin ⁵ Wang, Lin ⁶ Wang, Shengdian ⁷
作者单位：

1. Peking Union Med Coll, Canc Hosp, Dept Immunol, Beijing 100021, Peoples R China.

2. Peking Union Med Coll, Inst Canc, Beijing 100021, Peoples R China.

3. Chinese Acad Med Sci, Beijing 100730, Peoples R China.

4. Capital Med Univ, Dept Parasitol, Beijing, Peoples R China.

5. Peking Union Med Coll, Canc Hosp, Dept Pathol, Beijing 100021, Peoples R China.

6. Peking Union Med Coll, Inst Canc, Beijing 100021, Peoples R China.

7. Chinese Acad Sci, Inst Biophys, Ctr Infect & Immun, Beijing 100080, Peoples R China.
提交时间：2016-05-11 08:40:37

摘要: Granzyme M is a serine protease known to be often expressed by natural killer cells and induce target cells apoptosis in combination with perforin. However, we detected granzyme M expression in murine and human cancer cell lines and human tumor samples in our study. Granzyme M increased chemoresistance, colony-formation, cytokine secretion and invasiveness in vitro. Most importantly, granzyme M facilitated tumor growth and metastasis in vivo. Granzyme M induced the epithelial-mesenchymal transition (EMT) in cancer cells associated with STAT3 activation. Our study revealed the role of granzyme M expressed by tumor in chemoresistance, invasion, metastasis and EMT.

EXTRACELLULAR-MATRIX NK-CELL CANCER INFLAMMATION INVASION MICE LYMPHOCYTES CARCINOMA DEATH GENE

期刊： ONCOTARGET
分类： 生物学 >> 生物物理学 >> 肿瘤学
引用： ChinaXiv:201605.01295 (或此版本 ChinaXiv:201605.01295V1)
DOI:10.12074/201605.01295V1
CSTR:32003.36.ChinaXiv.201605.01295.V1
推荐引用方式： Wang, Huiru,Wu, Yanhong,Zhou, Chunxia,Ma, Wenbo,Zhang, Youhui,Zhang, Shuren,Wang, Huiru,Wu, Yanhong,Zhou, Chunxia,Ma, Wenbo,Zhang, Youhui,Zhang, Shuren,Wang, Huiru,Wu, Yanhong,Wang, Lin,Zhou, Chunxia,Ma, Wenbo,Zhang, Youhui,Zhang, Shuren,Sun, Qing,Wang, Lin,Wang, Lin,Wang, Shengdian.(2016).Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation.ONCOTARGET.[ChinaXiv:201605.01295] (点此复制)

版本历史

[V1]

2016-05-11 08:40:37

ChinaXiv:201605.01295V1

下载全文

相关论文推荐

1. Nrf1 acts as a highly-conserved determinon for maintaining robust redox homeostasis in the eco-evo-devo process of life histories	2024-05-24
2. Elucidating Electronic Structure Variations in Nucleic Acid-Protein Complexes Involved in Transcription Regulation Using a Tight-Binding Approach	2024-04-16
3. Do chondrocytes within calcified cartilage have a higher preservation potential than osteocytes? A preliminary taphonomy experiment	2023-03-14
4. Koisio Technology-Produced Water Significantly Decreased Inflammation and Multiple Injuries in Mouse Model of Dextran Sulfate Sodium Salt-Induced Acute Colon Inflammation	2022-12-04
5. Effects of native and invasive Prosopis species on topsoil physiochemical properties in an arid riparian forest of Hormozgan Province, Iran	2022-11-08
6. On the origin of SARS-CoV-2–The blind watchmaker argument	2021-07-17
7. Using Bayesian tip-dating method to estimate divergence times and evolutionary rates	2021-05-20
8. 2-Aminopyrimidine Derivatives as New Selective Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors	2020-11-24
9. The phylogenetic position of Cladiucha within Tenthredinidae based on comprehensive mitochondrial phylogenomics and the evidence from comparative analyses of rRNA secondary structure	2020-04-19
10. Restoration of brain consciousness ex vivo after circulatory death in pigs	2020-03-23


公开评论匿名评论仅发给作者