LSY-2 is essential for maintaining the germ-soma distinction in C-elegans

Subjects: Biology >> Biophysics >> Cell Biology submitted time 2016-05-12

Lin, Long Lin, Long Yan, Libo Zhao, Yu Lin, Long Li, Yuping Zhang, Gangming Zhang, Hong

Abstract： The mechanisms that specify and maintain the characteristics of germ cells during animal development are poorly understood. In this study, we demonstrated that loss of function of the zinc-finger gene lsy-2 results in various somatic cells adopting germ cells characteristics, including expression of germline-specific P granules, enhanced RNAi activity and transgene silencing. The soma to germ transformation in lsy-2 mutants requires the activities of multiple chromatin remodeling complexes, including the MES-4 complex and the ISW-1 complex. The distinct germline-specific features in somatic cells and the gene expression profile indicate that LSY-2 acts in the Mec complex in this process. Our study demonstrated that lsy-2 functions in the maintenance of the soma-germ distinction.

Peer Review Status:Awaiting Review

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