Subjects: Biology >> Botany >> Applied botany submitted time 2021-11-04 Cooperative journals: 《广西植物》
Abstract： Stephania kwangsiensis, a vine plant of the Stephaniaceae family, is mainly spread in Guangxi, China. The roots of S. kwangsiensis, “Jin Bu Huan” in Chinese, is often used for sedative, insecticidal, anti-inflammatory, anti-tumor, antiviral, anti-bacterial, as well as for the treatment of Alzheimer’s disease. In order to make full use of the title plant resources, clarify its chemical components, and find the relevant active compounds, the methanol extracts of non-medicinal parts of this plant was isolated using various chromatographic methods such as positive phase Sephadex LH-20, positive phase silica gel, positive phase polyamide, and MCI gel CHP 20P. The structures of the isolated components were determined by MS, 1H NMR, 13C NMR, and other spectroscopic data analysis, as well as comparison with relevant literatures. The activities of the isolated compounds from S. kwangsiensis against bacteria (Escherichia coli, Staphylococcus aureus, Bacillus subtilis) and fungi (Fusarium oxysporum) were evaluated using filter paper method. The results were as follows: (1) 10 compounds obtained from the non-medicinal parts of this plant were identified as vomifoliol (1), grasshopper ketone (2), isocorydine(3),2-O-β-D-glucopyranosyl-D-arabinitol(4),(9S,12S,13S)-trihydroxyoctadeca-(10E,15Z)-dienoic acid (5), magnoflorine (6), corchoionoside C (7), tormentic acid (8), corydine (9), and crebanine (10). Among of them, compounds 1, 2, 4, 5, 6, 7 and 8 were isolated from this plant for the first time. Compounds 1, 2, 4, 5, 7 and 8 were firstly obtained from this genus plants. And compound 4 was found from natural products for the first time. (2) At concentration of 6 mg·mL-1, Compounds 1, 2 and 5 show weak antibacterial activities against Escherichia coli; Compound 2 exhibits weak antibacterial activities against Staphylococcus aureus; Compounds 3 and 8 display weak antibacterial activities against Bacillus subtilis. The non-medicinal parts of Stephania kwangsiensis contains large numbers of active components and have the potential of development and utilization.
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