Subjects: Biology >> Microbiology Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2021-08-11
Abstract： By re-analzying public metagemonic data from 101 patients infected with influenza A virus from the 2007-2012 flu seasons in France, we identified artificially constructed recombinant SARS-CoV (SARSr-CoV) sequences in 22 samples, among which three were fully assembled. These sequences are highly similar to the recombinant SARSr-CoV strains generated by the J. Craig Venter Institute in USA, indicating the coexistence of SARS and H1N1 in these patients, which may be caused by possible co-infection or contamination accident. Our analysis also suggests that re-analyzing public metagenomic data is useful for retrospective studies on past outbreaks of infectious diseases. "
Peer Review Status:
Awaiting Review
Subjects: Biology >> Virology Subjects: Medicine, Pharmacy >> Preclinical Medicine submitted time 2021-07-28
Qihui Wang
Hua Chen
Yi Shi
Alice C. Hughes
William J. Liu
Jingkun Jiang
George F. Gao
Yongbiao Xue
Yigang Tong
Abstract： The origin of SARS-CoV-2 remains elusive. Understanding how, when, and where SARS-CoV-2 was transmitted from its natural reservoir to human beings is crucial for preventing future coronavirus outbreaks. With the lessons learned from the endless battle with pathogens and accumulated research data with regard to the origin and intermediate host, we present multiple potential locations as the natural reservoir of SARS-CoV-2.
Peer Review Status:Awaiting Review
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