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1. chinaXiv:201901.00071 [pdf]

Clinical study on Transcranial magnetoelectric encephalopathy treatment instrument treatmenting parkinson’s disease

Qiang Tang; Wei Zou; Zuodong Sun; Kang Li; Wuyi Sun; Wenhua Wang; Yanli Xing; Xueping Yu; Jing Bai; Xiuying Teng; Yan Hou
Subjects: Medicine, Pharmacy >> Clinical Medicine
Subjects: Physics >> Electromagnetism, Optics, Acoustics, Heat Transfer, Classical Mechanics, and Fluid Dynamics

[Objective] Evaluate on the treatment efficacy and safety for transcranial magnetoelectric encephalopathy treatment instrument (brand name: AOBO Parkinson’s Treatment Instrument) treatmenting parkinson's disease. [Methods] Use methods of double center,randomized, double blind, self crossover, 22 Parkinson’s patients who met the inclusion criteria were randomly divided into A group and B group, then were carried on the curative effect analysis, and were observed therapeutic effect. [Results] The treatment group of 22 cases, basically cured in 0 cases, markedly effective in 9 cases, effective in 8 cases, ineffective in 5 cases. The total efficiency rate and total effective rate were 40.91% (9/22) or 77.27% (17/22) respectively. The control group of 22 cases, basically cured in 0 cases, markedly effective in 2 cases, effective in 3 cases, ineffective in 17 cases. The total efficiency rate and total effective rate were 9.09% (2/22) or 22.73% (5/22) respectively, the total effective rate and total effective rate in the treatment group were higher than those in the control group, the difference was statistically significant (P<0.05). Among them, the main symptoms of resting tremor, rigidity, bradykinesia, evaluation, the treatment group has significant difference (P<0.01); There was no significant difference in the control group (p>0.05); There was significant difference between the treatment group and the control group (p<0.05). [Conclusions] Transcranial magnetoelectric stimulation can significantly improve resting tremor, muscle rigidity, bradykinesia in patients with Parkinson’s disease and other symptoms, and the use of safety. "

submitted time 2019-01-15 Hits22722Downloads1008 Comment 0

2. chinaXiv:201901.00070 [pdf]

重复经颅磁电刺激对海人酸致痫鼠的疗效研究

张旺; 王孝义; 郭洪渠; 宋媛媛; 王爱丽; 孙作东; 沈红
Subjects: Medicine, Pharmacy >> Clinical Medicine
Subjects: Physics >> Electromagnetism, Optics, Acoustics, Heat Transfer, Classical Mechanics, and Fluid Dynamics

目的 探讨经颅磁电刺激(TMES)疗法对海仁酸(KA)致颞叶癫痫鼠的疗效。 方法 62只大鼠按照随机数字表法分为预处理组(共32只)和治疗组(共30只),预处理组再分为4个小组,分别给予治疗仪最大电流强度(MCI) 0%,25%,50%,75%的电流刺激,确定本实验条件下的最佳刺激参数。治疗组再分为3个小组,每组10只。2组(癫痫刺激组、癫痫非刺激组)为符合纳入标准的癫痫模型大鼠,刺激组刺激参数为预处理组确定出的最佳刺激参数;非刺激组大鼠刺激前后处理与刺激组相同,但治疗仪无有效的能量输出。第3组对照组为未造模对照大鼠。3组大鼠均给予每天1次,40 min/次,共14 d的刺激。记录并比较3组大鼠行为学、电生理学及组织学变化,以评估TMES疗法对癫痫大鼠的疗效。 结果 50%MCI为最佳刺激强度。癫痫刺激组大鼠癫痫波出现的频率明显低于癫痫非刺激组大鼠[(30.210 ±4.580)次/min vs. (31.380 ± 4.247)次/min],差异有统计学意义(t=3.235,P=0.001)。Timm染色结果提示3组大鼠染色评分差异有统计学意义(F=17.429, P=0.000),癫痫刺激组大鼠海马齿状回的内分子层Timm染色评分较癫痫非刺激组明显减轻,差异有统计学意义(P<0.05)。结论 TMES疗法可通过改善癫痫大鼠海马齿状回内分子层组织学变化程度来影响齿状回神经元环路的形成,进而降低癫痫脑电波的发作频率。

submitted time 2019-01-02 Hits12745Downloads1043 Comment 0

3. chinaXiv:201703.00360 [pdf]

脑功能康复仪(脑康仪)对脑循环和脑功能的影响

焦明德; 徐丹枫; 李兰英; 于波; 孙作东
Subjects: Biology >> Bioengineering
Subjects: Physics >> Electromagnetism, Optics, Acoustics, Heat Transfer, Classical Mechanics, and Fluid Dynamics

[目的] 临床观察脑功能康复仪(脑康仪)对脑循环和脑功能的影响。[方法] 将脑血管病患者180例,分为脑梗塞组、脑动脉硬化症组、椎-基底动脉供血不足组,每组各60例,按来诊的先后次序分为药物治疗组和仪器治疗组,各30例。药物治疗组按各病种的治疗常规投药,仪器治疗组应用奥博脑复康治疗仪,连续治疗 30 天。选用反映脑血流动力学变化的经颅多普勒超声(TCD)和反映脑功能变化的脑电地形图(BEAM)作为观测指标。[结果] 在脑梗塞患者中实验组的疗效明显优于对照组(P﹤0.01),而且 TCD 和 BEAM 在两组间均呈现显著的差异性(P﹤0.05 或﹤0.01);在脑动脉硬化症患者中实验组的疗效优于对照组(P﹤0.05),而且 TCD 和 BEAM 在两组间均呈现显著的差异性(P﹤0.01)或﹤0.05);在椎-基底动脉供血不足患者中,实验组的疗效明显优于对照组(P﹤0.05),而且TCD、BEAM 在两组间亦呈现报为显著的差异性(P﹤0.01)。[结论] 应用脑康仪可明显改善脑血流动力学状态,增加脑血流量,强化脑的功能活动,消除脑部病灶周围的组织水肿和肿胀,缓解脑血管痉挛,改善脑组织的血液供给和缺氧状态提高脑组织的新陈代谢,促进病灶同侧或对侧的侧支循环形成,激活处于抑制状态的脑细胞,增强大脑的综合分析能力和记忆功能。可用于治疗脑梗塞、脑动脉硬化症、椎-基底动脉供血不足以及由于强化记忆所致脑功能减退。

submitted time 2017-03-17 Hits12063Downloads1729 Comment 0

4. chinaXiv:201701.00088 [pdf]

经颅磁电脑病治疗仪治疗血管性痴呆的临床研究

邹伟; 唐强; 孙作东; 邢艳丽; 于学平; 李康; 孙五一; 王文华; 刘波; 张立; 戴晓红; 侯艳
Subjects: Biology >> Bioengineering
Subjects: Physics >> Electromagnetism, Optics, Acoustics, Heat Transfer, Classical Mechanics, and Fluid Dynamics

[目的] 评价经颅磁电脑病治疗仪(商品名:奥博阿尔茨海默治疗仪)治疗轻、中度血管性痴呆(Vascular dementia,VD)的有效性及安全性。 [方法] 对80例轻、中度AD[Hachinski缺血量表评分≥7分,痴呆程度(CDR=1.0)或(CDR=2.0)]患者进行了随机、安慰对照、多中心4周临床试验,其中治疗组和对照组各40例。所有入选病例均给予正规的内科基础治疗和规范化护理,治疗组使用经颅磁电脑病治疗仪进行治疗,对照组使用模拟经颅磁电脑病治疗仪进行模拟治疗。 [结果] 治疗4周时,治疗组较对照组简易精神状态评价(MMSE)、临床痴呆程度量表( CDR) 和日常生活能力评价(ADL)分数显著改善(组间差异P依次<0.0001、0.05、0.05)。两组均无不良反应。 [结论] 经颅磁电脑病治疗仪治疗轻、中度血管性痴呆具有治疗效果,对患者的精神状态、认知行为和日常生活自理能力有较好的改善作用,且该治疗仪使用安全。

submitted time 2017-02-13 Hits19316Downloads1622 Comment 0

5. chinaXiv:201702.00004 [pdf]

脑细胞激活论

孙作东
Subjects: Biology >> Molecular Biology
Subjects: Biology >> Bioengineering
Subjects: Physics >> Electromagnetism, Optics, Acoustics, Heat Transfer, Classical Mechanics, and Fluid Dynamics

是一种基于经颅磁电刺激技术有效治疗帕金森病、阿尔茨海默病的新观点,可理解成电压门控钙离子通道物理激活最佳靶点假说,基本内容:帕金森病、阿尔茨海默病等神经元退行性变疾病,与物理门控离子通道密切相关,可用物理手段来解决,激活递质能神经元是治疗的关键,电压门控钙离子通道则是物理手段激活的最佳靶点,目的是诱导钙离子内流触发神经元轴突终末突触囊泡释放神经递质。脑细胞激活论,指出了阿尔茨海默病、帕金森病等神经元退行性变疾病的治疗原则、方法与目的,提示了试图通过药物化学手段来寻求神经元退行性变疾病的解决办法,可能会动摇我们应对疾病的信心,而物理手段的应用或物理化学手段的联合应用也许是我们今后应对一些重大脑病的主要科研方向。

submitted time 2017-02-04 Hits16509Downloads1926 Comment 0

6. chinaXiv:201701.00094 [pdf]

The theory of brain cell activation

Zuodong SUN
Subjects: Biology >> Cell Biology
Subjects: Biology >> Molecular Biology
Subjects: Physics >> Electromagnetism, Optics, Acoustics, Heat Transfer, Classical Mechanics, and Fluid Dynamics

This is a new idea that based on effective treatment of Parkinson's disease and Alzheimer's disease with transcranial magnetoelectric stimulation technology, it can understand a hypothesis about voltage-gated Ca2+ channels is the best target for activation by physical means, basic content:Parkinson's disease , Alzheimer's disease etc. neuronal degeneration diseases, that closely related to physical-gated ion channels, which can be treated with physical means, activating neurotransmitters-energic neurons plays key roles in the treatment, and voltage-gated Ca2+ channels is the best target for physical means, the purpose is to induce Ca2+ inflowing and triggers neuronal axon terminals synaptic vesicles releasing neurotransmitters. The theory of brain cell activation sets forth the principle, method and purpose of treatment of the physical gated ion channel diseases such as Alzheimer's disease, Parkinson's disease and other neural degeneration diseases, and indicates that the attempt to treat these diseases using pharmaceutical and chemical approaches could shake our confidence in conquering the diseases, and the application of physical approaches or combined application of physical and chemical approaches in the treatment of some major encephalopathy may be our main research direction in the future.

submitted time 2017-01-20 Hits17596Downloads1562 Comment 0

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