分类： 医学、药学 >> 临床医学 分类： 生物学 >> 生物工程 分类： 物理学 >> 电磁学、光学、声学、传热、经典力学和流体动力学 提交时间： 2019-01-15
Qiang Tang
Wei Zou
Zuodong Sun
Kang Li
Wuyi Sun
Wenhua Wang
Yanli Xing
Xueping Yu
Jing Bai
Xiuying Teng
Yan Hou
摘要： [Objective] Evaluate on the treatment efficacy and safety for transcranial magnetoelectric encephalopathy treatment instrument (brand name: AOBO Parkinson’s Treatment Instrument) treatmenting parkinson's disease. [Methods] Use methods of double center,randomized, double blind, self crossover, 22 Parkinson’s patients who met the inclusion criteria were randomly divided into A group and B group, then were carried on the curative effect analysis, and were observed therapeutic effect. [Results] The treatment group of 22 cases, basically cured in 0 cases, markedly effective in 9 cases, effective in 8 cases, ineffective in 5 cases. The total efficiency rate and total effective rate were 40.91% (9/22) or 77.27% (17/22) respectively. The control group of 22 cases, basically cured in 0 cases, markedly effective in 2 cases, effective in 3 cases, ineffective in 17 cases. The total efficiency rate and total effective rate were 9.09% (2/22) or 22.73% (5/22) respectively, the total effective rate and total effective rate in the treatment group were higher than those in the control group, the difference was statistically significant (P0.05); There was significant difference between the treatment group and the control group (p<0.05). [Conclusions] Transcranial magnetoelectric stimulation can significantly improve resting tremor, muscle rigidity, bradykinesia in patients with Parkinson’s disease and other symptoms, and the use of safety. "
分类： 医学、药学 >> 临床医学 分类： 生物学 >> 生物工程 分类： 物理学 >> 电磁学、光学、声学、传热、经典力学和流体动力学 提交时间： 2019-01-02
摘要： 目的 探讨经颅磁电刺激(TMES)疗法对海仁酸(KA)致颞叶癫痫鼠的疗效。 方法 62只大鼠按照随机数字表法分为预处理组(共32只)和治疗组(共30只)，预处理组再分为4个小组，分别给予治疗仪最大电流强度(MCI) 0%，25%，50%，75%的电流刺激，确定本实验条件下的最佳刺激参数。治疗组再分为3个小组，每组10只。2组(癫痫刺激组、癫痫非刺激组)为符合纳入标准的癫痫模型大鼠，刺激组刺激参数为预处理组确定出的最佳刺激参数；非刺激组大鼠刺激前后处理与刺激组相同，但治疗仪无有效的能量输出。第3组对照组为未造模对照大鼠。3组大鼠均给予每天1次，40 min/次，共14 d的刺激。记录并比较3组大鼠行为学、电生理学及组织学变化，以评估TMES疗法对癫痫大鼠的疗效。 结果 50%MCI为最佳刺激强度。癫痫刺激组大鼠癫痫波出现的频率明显低于癫痫非刺激组大鼠[(30.210 ±4.580)次/min vs. (31.380 ± 4.247)次/min]，差异有统计学意义(t=3.235，P=0.001)。Timm染色结果提示3组大鼠染色评分差异有统计学意义(F=17.429, P=0.000)，癫痫刺激组大鼠海马齿状回的内分子层Timm染色评分较癫痫非刺激组明显减轻，差异有统计学意义(P＜0.05)。结论 TMES疗法可通过改善癫痫大鼠海马齿状回内分子层组织学变化程度来影响齿状回神经元环路的形成，进而降低癫痫脑电波的发作频率。
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