Subjects: Biology >> Biophysics >> Integrative & Complementary Medicine submitted time 2016-05-12
Tan, Li
Chen, Weiwei
Wei, Ming-Yu
Shen, Jinhua
Yu, Meng-Fei
Liu, Qing-Hua
Tan, Li
Chen, Weiwei
Wei, Ming-Yu
Shen, Jinhua
Yu, Meng-Fei
Liu, Qing-Hua
Yang, Guangzhong
Guo, Donglin
Guo, Donglin
Qin, Gangjian
Ji, Guangju
Abstract： The traditional herb Plumula Nelumbinis is widely used in the world because it has many biological activities, such as anti-inflammation, antioxidant, antihypertension, and butyrylcholinesterase inhibition. However, the action of Plumula Nelumbinis on airway smooth muscle (ASM) relaxation has not been investigated. A chloroform extract of Plumula Nelumbinis (CEPN) was prepared, which completely inhibited precontraction induced by high K+ in a concentration-dependent manner in mouse tracheal rings, but it had no effect on resting tension. CEPN also blocked voltage-dependent L-type Ca2+ channel-(VDCC-) mediated currents. In addition, ACh-induced precontraction was also completely blocked by CEPN and partially inhibited by nifedipine or pyrazole 3. Besides, CEPN partially reduced ACh-activated nonselective cation channel (NSCC) currents. Taken together, our data demonstrate that CEPN blocked VDCC and NSCC to inhibit Ca2+ influx, resulting in relaxation of precontracted ASM. This finding indicates that CEPN would be a candidate of new potent bronchodilators.
Peer Review Status:
Awaiting Review
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