Subjects: Biology >> Other Disciplines of Biology submitted time 2023-04-20
Abstract：在古人类研究中，骨骼，尤其是头骨性状的测量是获得标本特征信息的主要手段。随着技术的发展，CT技术及三维复原技术为骨骼测量带来了巨大的便利。其中Mimics软件作为常用的三维重建软件之一，在复原过程中为使用者提供了低、中、高、最佳这四种精度的选择。我们希望获知在不同复原精度得到的模型上进行测量得到的结果存在何种程度的差异，以便在未来研究过程中选择最合适的标准。在本研究中，我们选择了顶骨矢状弦、颅周、头盖面积、乳突小房表面积、颅容量、乳突小房体积这六项性状的测量数据作为检测指标，计算同一批现代人标本在Mimics中采用不同精度复原得到的模型间测量数值的差异，根据Mimics的复原模型简化规则，我们选择未精简的最佳精度模型作为标准进行非参数检验、配对t检验及计算测量差异占比。结果表明，这六项的不同简化精度模型测量数据与最佳精度模型测量数据的非参数检验及配对t检验均具有显著差异。顶骨矢状弦、颅周、头盖面积、颅容量的测量差异占比基本均小于3%，而乳突小房表面积的低精度测量差异占比可达到50%以上，乳突小房体积低精度测量差异占比可达120%以上。除去简化过程造成的模型表面膨胀外，乳突小房的多气房结构造成不同精度之间存在的绝对差异比上一整体体量小区域而形成的巨大相对差异提示我们，在三维模型的测量中，对于头骨内部腔窦这样小体量表面粗糙的部分的复原精度选择及数据比较需要格外谨慎。
Subjects: Biology >> Virology submitted time 2020-02-22
Mu, Jingfang
Xu, Jiuyue
Shu, Ting
Wu, Di
Huang, Muhan
Ren, Yujie
Li, Xufang
Geng, Qing
Xu, Yi
Qiu, Yang
Zhou, Xi
Abstract： The SARS-CoV-2 outbreak has emerged and is still ongoing in Wuhan and other areas of China and world. Human infections by SARS-CoV-2 lead to diseases ranging from mild symptoms to severe pneumonia and even death. And in the current situation, better understanding of the virology and virus-host interactions of SARS-CoV-2 would be vital for the efforts to control the infections and develop effective therapies. RNA interference (RNAi) is an evolutionarily conserved antiviral immune mechanism in diverse eukaryotic organisms, and numerous viruses have been found to encode their own viral suppressors of RNAi (VSRs) as countermeasures. In this study, we uncovered that the nucleocapsid (N) protein encoded by SARS-CoV-2 effectively suppressed RNAi triggered by either small hairpin RNAs (shRNAs) or small interfering RNAs (siRNAs) in cultured human cells. Furthermore, similar with VSRs encoded by other viruses, SARS-CoV-2 N protein shows double-stranded RNA (dsRNA)-binding activity, as it interacted with in vitro transcribed dsRNAs in human cells. Taken together, our findings showed that SARS-CoV-2 N exhibits the VSR activity in human cells, which could be as a key immune evasion factor for SARS-CoV-2 and contribute to its pathogenicity. "
Peer Review Status:
Awaiting Review
Subjects: Biology >> Bioengineering submitted time 2017-07-24 Cooperative journals: 《中国生物工程杂志》
Abstract： Microalgae have been attracted as one of the potential sustainable bioresoucre due to their high photosynthetic efficiency, shorter growth cycle and enrichment of lipids, protein, carbohydrate, carotenoid and so on. Microalgae have high oil yield per unit area compared with other oilseed crops. In recent years, microalgae have been extensively investigated for biodiesel technology and CO2 emission reduction simultaneously. In addition, microalgae rich in a variety of high-value bioactive substances and have been widely applied in food, medicine and feed fields. The microalgal industry and corresponding research call the standard methods to evaluate the cultivated biomass from aspects. In this paper, it have been reviewed that the methods to examine the most interested components in quantification and quality prevail in order to promote the standardization for analysis of microalgal components in microalgal field.
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