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苍耳为民间传统药用植物,本课题组前期研究发现江西地产苍耳草大孔树脂50%乙醇洗脱部位具有显 著的抑制细胞坏死性凋亡(necroptosis)活性。为明确苍耳草的活性成分,活性部位采用反复硅胶柱色谱、 Sephadex LH-20 葡聚糖凝胶柱色谱、制备高效液相色谱、重结晶等多种方法进行分离和纯化,运用NMR、 MS 等波谱方法并结合文献数据对分离得到的化合物进行结构鉴定。从该活性部位中分离得到14 个化合物, 分别鉴定为hydroxydihydrobovolide(1)、树莓酮(2)、水杨醇(3)、对羟基苯乙酮(4)、对羟基苯甲醛 (5)、咖啡酸乙酯(6)、阿魏醛(7)、异东莨菪素(8)、3,3' –bis(3,4-dihydro-4-hydroxy-6-methoxy- 2H-1-benzopyran) (9)、axillarin (10)、槲皮素(11)、(+)松脂素(12)、β-谷甾醇(13)和棕榈酸(14)。化合物1、 2、3、4、7、8、9、10 为首次从苍耳草中分离得到。
[英文摘要]Herba Xanthii is a traditional folk medicinal plant.The 50% ethanol eluting faction of Xanthium mongolicum in Jiangxi had significant activity to inhibit necroptosis. In order to investigate the chemical constituents, the active fractions of X. sibiricum were isolated and purified by various chromatographic methods such as repeated silica gel column chromatography, Sephadex LH-20 column chromatography, preparative high performance liquid chromatography and recrystallization to yield 14 compounds. Their structures were established on the basis of NMR, MS spectraoscopic analyses and comparison with lirerature date. Fourteen compounds were isolated from the active part and identified as hydroxydihydrobovolide(1), raspberry ketone(2), salicyl alcohol(3), 4-hydroxyl-acetophenone(4), 4-hydroxybenzaldehyde(5), ethyl caffeate(6), ferulaldehyde(7), isoscopletin(8), 3,3'-bis(3,4-dihydro-4-hydroxy-6 -methoxy-2H-1-benzopyran)(9),axillarin (10),quercetin (11),(+) pinoresinol(12), β-sitosterol(13) and palmatic acid(14). Compounds 1, 2, 3, 4, 7, 8, 9, 10 were isolated from Xanthium mongolicum for the first time.
Download Comment Cooperative journals:《广西植物》 Hits:5093 Downloads:423
Recommended references: 盛天露,付璐鹭,许俊申,尚锐峰,陈钟文,刘峰,刘华.(2021).江西地产苍耳草抑制坏死性凋亡(necroptosis)活性部位化学成分研究(Ⅰ).广西植物.[ChinaXiv:202112.00132] (Click&Copy)
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[V1] 2021-12-19 21:30:36 chinaXiv:202112.00132V1 Download
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