摘要: The mechanisms that specify and maintain the characteristics of germ cells during animal development are poorly understood. In this study, we demonstrated that loss of function of the zinc-finger gene lsy-2 results in various somatic cells adopting germ cells characteristics, including expression of germline-specific P granules, enhanced RNAi activity and transgene silencing. The soma to germ transformation in lsy-2 mutants requires the activities of multiple chromatin remodeling complexes, including the MES-4 complex and the ISW-1 complex. The distinct germline-specific features in somatic cells and the gene expression profile indicate that LSY-2 acts in the Mec complex in this process. Our study demonstrated that lsy-2 functions in the maintenance of the soma-germ distinction.
-
期刊:
PROTEIN & CELL
-
分类:
生物学
>>
生物物理学
>>
细胞生物学
-
引用:
ChinaXiv:201605.01481
(或此版本
ChinaXiv:201605.01481V1)
doi:10.12074/201605.01481
CSTR:32003.36.ChinaXiv.201605.01481.V1
- 推荐引用方式:
Lin, Long,Lin, Long,Yan, Libo,Zhao, Yu,Lin, Long,Li, Yuping,Zhang, Gangming,Zhang, Hong.(2016).LSY-2 is essential for maintaining the germ-soma distinction in C-elegans.PROTEIN & CELL.[ChinaXiv:201605.01481]
(点此复制)