摘要: Hepatocellular carcinoma (HCC) is the most prevalent subtype of liver cancer, and it is characterized by a high rate of recurrence and heterogeneity. Liver cancer stem cells (CSCs) may well contribute to both of these pathological properties, but the mechanisms underlying their self-renewal and maintenance are poorly understood. Here, using transcriptome microarray analysis, we identified a long noncoding RNA (IncRNA) termed IncTCF7 that is highly expressed in HCC tumors and liver CSCs. LncTCF7 is required for liver CSC self-renewal and tumor propagation. Mechanistically, IncTCF7 recruits the SWI/SNF complex to the promoter of TCF7 to regulate its expression, leading to activation of Wnt signaling. Our data suggest that IncTCF7-mediated Wnt signaling primes liver CSC self-renewal and tumor propagation. In sum, therefore, we have identified an IncRNA-based Wnt signaling regulatory circuit that promotes tumorigenic activity in liver cancer stem cells, highlighting the role that IncRNAs can play in tumor growth and propagation.
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期刊:
CELL STEM CELL
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分类:
生物学
>>
生物物理学
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引用:
ChinaXiv:201605.01301
(或此版本
ChinaXiv:201605.01301V1)
DOI:10.12074/201605.01301V1
CSTR:32003.36.ChinaXiv.201605.01301.V1
- 推荐引用方式:
Wang, Yanying,Du, Ying,Zhu, Pingping,Huang, Guanling,Yan, Xinlong,Ye, Buqing,Li, Chong,Xia, Pengyan,Zhang, Geng,Fan, Zusen,He, Lei,Huang, Guanling,Fan, Zusen,Luo, Jianjun,Tian, Yong,Chen, Runsheng.(2016).The Long Noncoding RNA IncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling.CELL STEM CELL.[ChinaXiv:201605.01301]
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